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Đề tài - Dự án
TRANG CHỦ
TẠP CHÍ
BÀI BÁO
Số ra
Số 6/2020 EN
Tên bài báo
EXPRESSION OF IL6 mRNA IS INDEPENDENT WITH EXPRESSION OF TLRS mRNA IN LIPOPOLYSACCHARIDE-TREATED MYOTUBES
Tóm tắt
Obesity-related metabolic disorders such as insulin resistance and type 2 diabetes are raising as critical health problems of the modern world. Obesity induces an increased plasma level of lipopolysaccharide (LPS) that contributing to system chronic inflammation. This response has been shown as a marked factor linking obesity and its related metabolic disorders. In the present study, we use LPS to treat C2C12 skeletal muscle cells and observe the expression of several inflammatory makers. Our results show that the expression of inflammatory cytokine IL6 mRNA is strongly induced in the LPS-treated C2C12 cells compared to the control cells. Surprisingly, the expression of the upper controller of inflammation TLR2 mRNA in the LPS-treated C2C12 cells is similar to that in the control cells. Consistent with this expression mRNA level of TLR4, another upper regulator of inflammation does not differ between the two group cells. Taken together, our current data suggest that the LPS induced expression of IL6 mRNA in C2C12 cells is not dependent on the regulation of neither TLR2 nor TLR4
Tác giả
Le Ngoc Hoan, Chu Dinh Toi, Nguyen Phuc Hung and Ho Thi Hong Van
Mã phân loại
DOI: 10.18173/2354-1059.2020-0037
Chuyên ngành
.
Từ khoá
Lipopolysaccharide, myotubes, inflammation.
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