| Tóm tắt |
Obesity and overweight have become a leading health problem in the world. But we have not yet had any optimal therapy to prevent this health issue. Accumulating evidence suggests that there is existence of functional brown\brite adipocytes in both infants and adult humans, and the activated brown\brite can burn energy by generating heat. These adipocytes can be differentiated from stem cells and transplantation of pre-activated human thermogenic adipocytes in vitro benefits to glucose homeostasis, insulin sensitivity and reduces body fat in normal or obese immunodeficient mice. These investigations lead us to hypothesize a homologous stem cell therapy to treat obesity and its related disorders. The therapy bases on functional brown\brite adipocytes which are differentiated from homologous stem cells isolated from fat depot of an obese person, and those adipocytes are activated to have a full thermogenic program before being transplanted back to that patient to improve glucose homeostasis and reduce fat content. |